ACTIVITY OF SUPEROXIDE DISMUTASE AND CATALASE IN ERYTHROCYTES AND MALONDIALDEHYDE CONCENTRATION IN THE LIVER OF RATS EXPOSED TO Bi 58 NOWY AND PYRANTEL

The effect of an administration of Bi 58 Nowy (38% dimethoate) and/or pyrantel embonate on the activity of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and on malondialdehyde (MDA) concentration in rat liver homogenates was investigated. Bi 58 Nowy was administered for 4 weeks with drinking water at a dose of 15.48 mg/kg b.w. (1/25 LD50). Pyrantel embonate was given with a stomach probe at a dose of 1 000 mg/kg b.w., twice at two-week interval, i.e. on days 14 and 28. It was found that a 4-week exposure of rats to Bi 58 Nowy resulted, especially during the first hours after exposure, in an increase in SOD and CAT activity in erythrocytes and MDA content in rat liver homogenates, as compared to the control group. This may indicate that oxidative stress has appeared. The profile of changes in the examined parameters in combined intoxication was similar to those that were observed after the administration of only Bi 58 Nowy, but the changes were more pronounced.